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Daily Archives: July 28, 2021

– 2021/10/01: New review published in DNA Repair. Congrats Daisy!

A new review headed by Daisy proposes the existence of two classes of R-loops characterized by distinct properties with implications for our understanding of the relationship between R-loops and genome instability.

Fig. 1

Schematic of proposed classes of R-loops: “promoter-paused” R-loops and “elongation-associated” R-loops. Shading represents population distribution of R-loops for the two classes.

Promoter-paused R-loops are best captured under native conditions and occur in the immediate surrounding of the promoter region and transcription start site. Elongation-associated R-loops form throughout the gene body and transcription termination site.


Here are the links to the work: