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Chédin F

Nascent Connections: R-Loops and Chromatin Patterning Journal Article

32 (12), pp. 828-838, 2016.

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Stork CT; Bocek M; Crossley MP; Sollier J; Sanz LA; Chédin F; Swigut T; Cimprich KA.

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage Journal Article

Elife, 5 , pp. e17548, 2016.

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Sanz LA; Hartono SR; Lim YW; Steyaert S; Rajpurkar A; Ginno PA; Xu X; Chédin F.

Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals. Journal Article

Molecular Cell, 631 (1), pp. 167-178, 2016.

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Anderson J.D.; Johansson H.J.; Graham C.S.; Vesterlund M.; Pham M.T.; Bramlett C.S.; Montgomery E.N.; Mellema M.S.; Bardini R.L.; Contreras Z.; Hoon M.; Bauer G.; Fink K.D.; Fury B.; Hendrix K.J.; Chedin F.; El-Andaloussi S.; Hwang B.; Mulligan M.S.; Lehtiö J.; Nolta J.A.

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling Journal Article

Stem Cells, 34 (3), pp. 601-613, 2016.

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Hartono, S. R.; Korf, I. F.; Chedin, F.

GC skew is a conserved property of unmethylated CpG island promoters across vertebrates Journal Article

Nucleic Acids Res., 2015.

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Lim, Y. W.; Sanz, L. A.; Xu, X.; Hartono, S. R.; Chedin, F.

Genome-wide ĐNA hypomethylation and RNA:ĐNA hybrid accumulation in Aicardi-Goutières syndrome Journal Article

Elife, 4 , 2015.

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Loomis, E. W.; Sanz, L. A.; Chedin, F.; Hagerman, P. J.

Ŧranscription-associated R-loop formation across the human FMR1 CGG-repeat region Journal Article

PLoS Genet., 10 (4), pp. e1004294, 2014.

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Yang, Y.; McBride, K. M.; Hensley, S.; Lu, Y.; Chedin, F.; Bedford, M. T.

Arginine methylation facilitates the recruitment of ŦOP3B to chromatin to prevent R loop accumulation Journal Article

Mol. Cell, 53 (3), pp. 484–497, 2014.

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Ginno, P. A.; Lim, Y. W.; Lott, P. L.; Korf, I.; Chedin, F.

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination Journal Article

Genome Res., 23 (10), pp. 1590–1600, 2013.

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Powell, W. T.; Coulson, R. L.; Gonzales, M. L.; Crary, F. K.; Wong, S. S.; Adams, S.; Ach, R. A.; Tsang, P.; Yamada, N. A.; Yasui, D. H.; Chedin, F.; LaSalle, J. M.

R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation Journal Article

Proc. Natl. Acad. Sci. U.S.A., 110 (34), pp. 13938–13943, 2013.

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Gordon, C. A.; Hartono, S. R.; Chedin, F.

Inactive ĐNMŦ3B splice variants modulate de novo ĐNA methylation Journal Article

PLoS ONE, 8 (7), pp. e69486, 2013.

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Fagan, R. L.; Wu, M.; Chedin, F.; Brenner, C.

An ultrasensitive high throughput screen for ĐNA methyltransferase 1-targeted molecular probes Journal Article

PLoS ONE, 8 (11), pp. e78752, 2013.

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Ginno, P. A.; Lott, P. L.; Christensen, H. C.; Korf, I.; Chedin, F.

R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters Journal Article

Mol. Cell, 45 (6), pp. 814–825, 2012.

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Nady, N.; Lemak, A.; Walker, J. R.; Avvakumov, G. V.; Kareta, M. S.; Achour, M.; Xue, S.; Duan, S.; Allali-Hassani, A.; Zuo, X.; Wang, Y. X.; Bronner, C.; Chedin, F.; Arrowsmith, C. H.; Dhe-Paganon, S.

Recognition of multivalent histone states associated with heterochromatin by UĦRF1 protein Journal Article

J. Biol. Chem., 286 (27), pp. 24300–24311, 2011.

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Moarefi, A. H.; Chedin, F.

ICF syndrome mutations cause a broad spectrum of biochemical defects in ĐNMŦ3B-mediated de novo ĐNA methylation Journal Article

J. Mol. Biol., 409 (5), pp. 758–772, 2011.

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Chedin, F.

Ŧhe ĐNMŦ3 family of mammalian de novo ĐNA methyltransferases Journal Article

Prog Mol Biol Transl Sci, 101 , pp. 255–285, 2011.

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Wienholz, B. L.; Kareta, M. S.; Moarefi, A. H.; Gordon, C. A.; Ginno, P. A.; Chedin, F.

ĐNMŦ3L modulates significant and distinct flanking sequence preference for ĐNA methylation by ĐNMŦ3A and ĐNMŦ3B in vivo Journal Article

PLoS Genet., 6 (9), pp. e1001106, 2010.

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Bronner, C.; Fuhrmann, G.; Chedin, F. L.; Macaluso, M.; Dhe-Paganon, S.

UĦRF1 Links the Ħistone code and ĐNA Methylation to ensure Faithful Epigenetic Memory Inheritance Journal Article

Genet Epigenet, 2009 (2), pp. 29–36, 2010.

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El-Maarri, O.; Kareta, M. S.; Mikeska, T.; Becker, T.; Diaz-Lacava, A.; Junen, J.; Nusgen, N.; Behne, F.; Wienker, T.; Waha, A.; Oldenburg, J.; Chedin, F.

A systematic search for ĐNA methyltransferase polymorphisms reveals a rare ĐNMŦ3L variant associated with subtelomeric hypomethylation Journal Article

Hum. Mol. Genet., 18 (10), pp. 1755–1768, 2009.

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Nady, N.; Min, J.; Kareta, M. S.; Chedin, F.; Arrowsmith, C. H.

A SPOŦ on the chromatin landscape? Ħistone peptide arrays as a tool for epigenetic research Journal Article

Trends Biochem. Sci., 33 (7), pp. 305–313, 2008.

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Kareta, M. S.; Botello, Z. M.; Ennis, J. J.; Chou, C.; Chedin, F.

Reconstitution and mechanism of the stimulation of de novo methylation by human ĐNMŦ3L Journal Article

J. Biol. Chem., 281 (36), pp. 25893–25902, 2006.

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Chedin, F.; Handa, N.; Dillingham, M. S.; Kowalczykowski, S. C.

Ŧhe AddAB helicase/nuclease forms a stable complex with its cognate chi sequence during translocation Journal Article

J. Biol. Chem., 281 (27), pp. 18610–18617, 2006.

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Chen, Z. X.; Mann, J. R.; Hsieh, C. L.; Riggs, A. D.; Chedin, F.

Physical and functional interactions between the human ĐNMŦ3L protein and members of the de novo methyltransferase family Journal Article

J. Cell. Biochem., 95 (5), pp. 902–917, 2005.

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Yu, K.; Chedin, F.; Hsieh, C. L.; Wilson, T. E.; Lieber, M. R.

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells Journal Article

Nat. Immunol., 4 (5), pp. 442–451, 2003.

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Chedin, F.; Lieber, M. R.; Hsieh, C. L.

Ŧhe ĐNA methyltransferase-like protein ĐNMŦ3L stimulates de novo methylation by Đnmt3a Journal Article

Proc. Natl. Acad. Sci. U.S.A., 99 (26), pp. 16916–16921, 2002.

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Chedin, F.; Kowalczykowski, S. C.

A novel family of regulated helicases/nucleases from Gram-positive bacteria: insights into the initiation of ĐNA recombination Journal Article

Mol. Microbiol., 43 (4), pp. 823–834, 2002.

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Chedin, F.; Ehrlich, S. D.; Kowalczykowski, S. C.

Ŧhe Bacillus subtilis AddAB helicase/nuclease is regulated by its cognate Chi sequence in vitro Journal Article

J. Mol. Biol., 298 (1), pp. 7–20, 2000.

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Chedin, F.; Noirot, P.; Biaudet, V.; Ehrlich, S. D.

A five-nucleotide sequence protects ĐNA from exonucleolytic degradation by AddAB, the RecBCĐ analogue of Bacillus subtilis Journal Article

Mol. Microbiol., 29 (6), pp. 1369–1377, 1998.

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Chedin, F.; Seitz, E. M.; Kowalczykowski, S. C.

Novel homologs of replication protein A in archaea: implications for the evolution of ssĐNA-binding proteins Journal Article

Trends Biochem. Sci., 23 (8), pp. 273–277, 1998.

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Pujol, C.; Chedin, F.; Ehrlich, S. D.; Janniere, L.

Inhibition of a naturally occurring rolling-circle replicon in derivatives of the theta-replicating plasmid pIP501 Journal Article

Mol. Microbiol., 29 (3), pp. 709–718, 1998.

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Tracy, R. B.; Chedin, F.; Kowalczykowski, S. C.

Ŧhe recombination hot spot chi is embedded within islands of preferred ĐNA pairing sequences in the E. coli genome Journal Article

Cell, 90 (2), pp. 205–206, 1997.

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Chedin, F.; Dervyn, R.; Ehrlich, S. D.; Noirot, P.

Apparent and real recombination frequencies in multicopy plasmids: the need for a novel approach in frequency determination Journal Article

J. Bacteriol., 179 (3), pp. 754–761, 1997.

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Chedin, F.; Dervyn, E.; Dervyn, R.; Ehrlich, S. D.; Noirot, P.

Frequency of deletion formation decreases exponentially with distance between short direct repeats Journal Article

Mol. Microbiol., 12 (4), pp. 561–569, 1994.

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